The kinetic mechanism of the major form of ox kidney aldehyde reductase with d-glucuronic acid
- 1 August 1982
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 205 (2) , 381-388
- https://doi.org/10.1042/bj2050381
Abstract
The steady-state kinetics of the major form of ox kidney aldehyde reductase with D-glucuronic acid were determined at pH 7. Initial rate and product inhibition studies performed in both directions are consistent with a Di-Iso Ordered Bi Bi mechanism. The mechanism of inhibition by sodium valproate and benzoic acid is shown to involve flux through an alternative pathway.This publication has 25 references indexed in Scilit:
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