A SEQUENTIAL STUDY OF INTRAVENOUS ANALGESIC TREATMENT DURING LABOUR

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Abstract
A sequential study of intravenous analgesic treatment during labour has shown that pentazocine 40 mg provides pain relief comparable to pethidine 100 mg alone or combined with levallorphan 1.25 mg (Pethilorfan), but is significantly more effective than pethidine 50 mg. Pethilorfan gave less sustained analgesia and a high incidence of dysphoria. Emetic sequelae were much more frequent with either dose of pethidine than with pentazocine. Placebo treatment was easily identified by mother and observer. Its inclusion and early sequential exclusion may have had a significant effect on observer estimations of pain relief. The effect of the treatments on labour or on the condition of the infant at birth were not studied.

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