Hepatic Synthesis of Alpha 2 (Acute Phase)-Globulin of Rat Plasma

Abstract
Synthesis of plasma alpha2 (acute phase)-globulin was demonstrated in isolated perfused rat liver obtained from animals showing acute inflammatory reaction to injury. These findings indicate that the liver is a source of the globulin and that appearance of this protein in the serum results from de novo synthesis by the liver rather than from release of performed and stored globulin.