Anti‐Sympathetic Action of Sympathomimetic Amines

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Abstract
Summary.: The effect of fourteen sympathomimetic amines has been studied on isolated strips of rabbit's intestine with special regard to their ability to antagonize the inhibition produced by adrenaline and l‐nor‐adrenaline as well as by electrical stimulation of the mesenteric nerves.For the sake of discussion the amines have been divided into three classes and each class described.The anti‐sympathetic property earlier reported for ephedrine and l‐N‐ethylephedrine has proven to be a rather common characteristin of the synipathoininietic amines. The only amines which did not have the anti‐sympathetic action were the dihydroxy‐phenyl substitutesi. e. adrenaline, arterenol, and aludrin (boehringer). The anti‐sympathetic action that was sometimes observed for adrenaline and aludrin has been ascribed to some derivatives formed during the ositlization of these compounds.d‐ and l‐forms of ephedrine and benzedrine have proven to be almost identical in their effects upon the intestine per se, as well as in respect to the anti‐sympathetic action. This has been considered as an argument against the allline oxidase theory.The anti‐sympathetic action of the sympathomimetic amines has Leen briefly discussed upon a chemical basis. The idea is propounded that the anti‐sympathetic action of these amines is an example of phanuacological competition.

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