Adverse Reactions to Prolonged treatment with High Doses of Carbenicillin and Ureidopenicillins

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Abstract
Charts were reviewed for 63 patients whose chronic pseudomonas osteomyelitis was treated with high doses of extended-spectrum penicillins for prolonged periods. The incidence of untoward drug reactions was significantly higher than expected. Carbemcillin evoked adverse reactions in 22.8% of patients. However, most of these reactions were mild, and a change of drug was required in only 5.7% of cases. No adverse drug reactions were observe~ WIth cuumulative doses of 250 g produced adverse reactions; and discontinuation or change of therapy was required in 51.6% of cases. The main adverse reactions to both carbemcilll? and the ureidopemcillins included rash, drug fever,leukopenia, eosinophilia, thrombocytopema, and hepatic damage.

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