The Heart Is a Target Organ for Androgen
- 15 February 1980
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 207 (4432) , 775-777
- https://doi.org/10.1126/science.6766222
Abstract
Autoradiographic and biochemical analyses of the hearts of female rhesus monkeys and baboons indicate that atrial and ventricular myocardial cells contain androgen receptors. Although the specific effects of nuclear uptake and retention of androgen on the function of heart muscle cells are not known, the presence of this receptor suggests that sex steroid hormones may affect myocardial function directly and may explain some of the peculiar differences in heart disease between men and women.Keywords
This publication has 6 references indexed in Scilit:
- Demonstration of a Specific Androgen Receptor in Rat Heart Muscle: Relationship between Binding, Metabolism, and Tissue Levels of Androgens*Endocrinology, 1978
- Effects of Sex Hormones on Cardiovascular and Hematologic Responses to Chronic Hypoxia in RatsExperimental Biology and Medicine, 1978
- The Heart: A Target Organ for EstradiolScience, 1977
- Equilibrium binding of estradiol by uterine cell suspensions and whole uteri in vitroBiochemistry, 1974
- Inhibition of noradrenaline uptake2 in the isolated rat heart by steroids, clonidine and methoxylated phenylethylaminesEuropean Journal of Pharmacology, 1972
- ENHANCEMENT OF NORADRENALINE PRESSOR RESPONSES IN TESTOSTERONE‐TREATED CATSBritish Journal of Pharmacology and Chemotherapy, 1967