Polyacetylene Analogs, Isolated from Hairy Roots ofPanax ginseng, Inhibit Acyl-CoA : Cholesterol Acyltransferase

1 December 1997

journal article
letter
Published by Georg Thieme Verlag KG in Planta Medica

Vol. 63 (06) , 552-553
https://doi.org/10.1055/s-2006-957763

Abstract

In the course of our screening program for acyl-CoA: cholesterol acyltransferase (ACAT) inhibitors from Korean herbal medicines, ACAT inhibitors were isolated from the hairy roots of Panax ginseng (Araliaceae) and identified as panaxynol, panaxydol, panaxydiol, and panaxytriol. These active compounds inhibit rat liver ACAT with IC₅₀ values of 94, 80, 45 and 79 µM, respectively.

Keywords

HAIRY ROOTS
GINSENG
ACYLTRANSFERASE
COA
MEDICINES
PANAXYTRIOL

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