Established major coronary risk factors: historical overview

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Abstract
This chapter presents a historical overview of research on the six established major risk factors for coronary heart disease: adverse diet, diet-related above-optimal levels of serum total cholesterol (TC), blood pressure (BP), overweight/obesity, diabetes mellitus (DM), and cigarette smoking. These have been shown to be centrally involved in the multifactorial causation of severe atherosclerotic disease, its complications, and its multiple clinical manifestations — first and foremost the epidemic of CHD in Western industrialized countries.