Imidazole: Fungitoxic Derivatives
- 15 December 1967
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 158 (3807) , 1462-1463
- https://doi.org/10.1126/science.158.3807.1462
Abstract
Study of several new types of fungitoxic derivatives of imidazole reveals that imidazoles substituted on the imine nitrogen atom are likely to be active if the substituent is electron-attracting, and if the atom connecting it to the imidazolyl moiety has tetrahedral geometry. Fungitoxicity is high with phosphinamidothionate and triarylmethyl groups as substituents. The presence of an asymmetric phosphorus atom in the substituent has no effect on fungitoxicity, but affects mammalian toxicity.Keywords
This publication has 12 references indexed in Scilit:
- ImidazolylphosphinamidothionatesJournal of Medicinal Chemistry, 1967
- Fungicidal PhthalimidophosphonothionatesScience, 1967
- Biological Activity of PhosphoramidothionatesNature, 1966
- ACUTE MAMMALIAN TOXICITY AND STRUCTURE OF HETEROCYCLIC ORGANOPHOSPHORUS COMPOUNDSAnnals of the New York Academy of Sciences, 1966
- The synthesis of optically active isopropyl methylphosphonofluoridate (Sarin): (Preliminary communication)Recueil des Travaux Chimiques des Pays-Bas, 1966
- Reactions of NN-diphenylcarbamoyl chloride. II. With amines, thiols, and imidazolesAustralian Journal of Chemistry, 1966
- The acute toxicity of pesticides to ratsToxicology and Applied Pharmacology, 1960
- Beiträge zur Chemie der Thiophosphate. VII. Optisch aktive ThiophosphateJournal für Praktische Chemie, 1959
- Untersuchungen über 1‐Triphenylmethyl‐imidazole, IEuropean Journal of Inorganic Chemistry, 1959
- The Stereochemistry of Asymmetric Phosphorus Compounds. II. Stereospecificity in the Irreversible Inactivation of Cholinesterases by the Enantiomorphs of an Organophosphorus InhibitorJournal of the American Chemical Society, 1958