Viremic Phase in a Leukemic Child After Live Varicella Vaccination
- 1 January 1992
- journal article
- case report
- Published by American Academy of Pediatrics (AAP) in Pediatrics
- Vol. 89 (1) , 147-149
- https://doi.org/10.1542/peds.89.1.147
Abstract
Live varicella vaccine has been shown to be efficacious for prevention of varicella even in immunocompromised children.1-4 Although the site and extent of viral replication in vaccinated hosts have not been fully defined, vaccinees have developed humoral and cellular immunity.1-5 A viremic phase has been demonstrated in immunocompromised and normal children with natural varicella.6,7 However, a viremic phase has not been reported in vaccinated children. We report our observation of viremia in a leukemic child in whom vesicles and hepatitis developed after live varicella vaccination. MATERIALS AND METHODS Human embryonic lung fibroblasts (HEFs) were used for virus isolation. The cells were grown in 25-cm2 plastic tissue culture flasks containing Eagle's minimal essential medium with 7.5% fetal bovine serum.Keywords
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