Construction of Chiral 1,2-Cycloalkanopyrrolidines from L-Proline Using Ring Closing Metathesis (RCM).

1 January 2000

journal article
Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN

Vol. 48 (10) , 1593-1596
https://doi.org/10.1248/cpb.48.1593

Abstract

An efficient synthetic method for the preparation of optically active pyrroloazocine, pyrroloazepine, quinolizidine, indolizidine using ring closing olefin metathesis (RCM) is described.

Keywords

OLEFIN
EFFICIENT
OPTICALLY
CYCLOALKANOPYRROLIDINES
CHIRAL
PROLINE
INDOLIZIDINE
QUINOLIZIDINE
PYRROLOAZOCINE
PYRROLOAZEPINE

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