Centrally Acting Muscle Relaxant Effect of Phthalides (Ligustilide, Cnidilide and Senkyunolide) Obtained from Cnidium officinale MAKINO
Open Access
- 1 January 1989
- journal article
- research article
- Published by Pharmaceutical Society of Japan in YAKUGAKU ZASSHI
- Vol. 109 (6) , 402-406
- https://doi.org/10.1248/yakushi1947.109.6_402
Abstract
The present study was carried out to elucidate as centrally acting muscle relaxant effect of chloroform soluble fraction and its component, namely, ligustilide, cnidilide and senkyunolide obtained from the rhizome of Cnidium Officinael MAKINO. These three compounds were isoalted from the chloroform solube fraction by column chromatography on silical gel. The centrally acting muscle relaxant effect was investigated on the crossed extensor reflex in anesthetized rats and these samples were suspended in 0.5% carboxymethyl cellulose solution and administered i.p. These three compounds as well as the chloroform soluble fraction depressed the reflex response. The depressive potencies among them were almost the same and their potencies were also the same or somewhat weaker as that of mephenesin. As a curare-like action was not observed, a muscle relaxation induced by these phthalide compounds is considered to be due to central origin.Keywords
This publication has 1 reference indexed in Scilit:
- Studies on the Constituents of Umbelliferae Plants. II. Isolation of the Active Principles of Ligusticum RootCHEMICAL & PHARMACEUTICAL BULLETIN, 1960