Inherited or Acquired Disorders of Blood Coagulation in Children with Neurovascular Complications

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Abstract
Congenital or acquired disorders of hemostasis can cause thrombotic events in adults as well as in children. Recently, acute neurologic complications such as hemiparesis or transitory ischemic attacks (TIA) have been reported in patients with different disorders of hemostasis. In addition, the interaction between anionic antiphospholipid antibodies and inhibition of the coagulation have to be considered for these clinical manifestation. This review aims at putting the clinical and experimental data which are currently available for children into perspective. Abbreviations APA: antiphospholipid antibodies AT III : antithrombin III CLA: cardiolipin antibody Ig: immunoglobulin LA: lupus anticoagulant PA: plasminogen activator inhibitor PC: protein C PCa: activated protein C PS: protein S PTT: partial thromboplastin time

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