Enhanced Red Blood Cell Aggregation Unrelated to Fibrinogen: A Possible Stroke Mechanism in Young Patients

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Abstract
In many young stroke patients the cause of stroke remains unclear. Enhanced red blood cell aggregation is considered a factor related to the pathogenesis of stroke in elderly patients, in whom enhanced red blood cell aggregation is correlated with increased fibrinogen. We determined red blood cell aggregation, fibrinogen concentration, hematocrit value and erythrocyte sedimentation rate in 18 stroke patients ≤ 50 years of age in the early phase and in 40 stroke patients ≤ 50 years in the late phase, and compared the values with those in young control persons. We also determined these variables in stroke patients ≤ 60 years of age in the early and in the late phases and in elderly controls. In young stroke patients we found an enhanced red blood cell aggregation compared with young controls (p

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