COMPARISON OF THE EFFECT OF DIISOPROPYL PHENOL (ICI 35 868) AND THIOPENTONE ON RESPONSE TO SOMATIC PAIN

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Abstract
The response to somatic pain with sub-hypnotic doses of ICI 35 868 (dusopropyl phenol in cremophor) and thiopentone was compared using tibial pressure algesimetry. Studies were also earned out following recovery from larger doses of both drugs. The patients underwent minor gynaecological procedures using only one of the two i.v. agents and nitrous oxide in oxygen. The studies confirmed the known antanalgesic action of thiopentone and demonstrated that dusopropyl phenol has an analgesic action which is an attractive feature in an i v anaesthetic agent.