Distribution of sulfur-35- and gold-198-labeled gold thioglucose in mice

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Abstract
Radioactive gold thioglucose was prepared using gold-198 and sulfur-35. It was administered in normal saline solution to female Rockland Swiss mice between 4 and 5 weeks of age and weighing approximately 20 gm. The labeled compound was given at a dose of 1 mg/gm of body weight and the radioactive dose was 0.2 uc/gm. The distribution of the labeled compound was determined at intervals of 30 minutes, 2, 6, 18 and 48 hours. The hypothalamic levels of radioactivity of mice treated with both sulfur-35- and gold-198-labeled gold thioglucose were significantly greater than those of the hindbrain and cerebrum at all time intervals with the exception of the hindbrain at 30 minutes. Autoradiographs of mice treated with gold-198-labeled material showed a localization of radioactivity in the diencephalon, which contains the hypothalamus. The kidney had the highest concentration of both labeled compounds at 30 minutes, and adrenal values were close to those of the kidney. Lesser degrees of radioactivity were found in the spleen, liver, muscle and blood.

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