MRI-based localization of electrophysiological recording sites within the cerebral cortex at single-voxel accuracy
- 17 December 2006
- journal article
- research article
- Published by Springer Nature in Nature Methods
- Vol. 4 (2) , 161-168
- https://doi.org/10.1038/nmeth987
Abstract
The localization of microelectrode recording sites in the layers of primate cerebral cortex permits the analysis of relationships between recorded neuronal activities and underlying anatomical connections. We present a magnetic resonance imaging method for precise in vivo localization of cortical recording sites. In this method, the susceptibility-induced effect thickens the appearance of the microelectrode and enhances the detectability of the microelectrode tip, which usually occupies less than a few percent of the volume of an image voxel. In a phantom study, the optimized susceptibility-induced effect allowed tip detection with single-voxel accuracy (in-plane resolution, 50 μm). We applied this method to recording microelectrodes inserted into the brains of macaque monkeys, and localized the microelectrode tip at an in-plane resolution of 150 μm within the cortex of 2–3 mm in thickness. Subsequent histological analyses validated the single-voxel accuracy of the in vivo tip localization. This method opens up a way to investigate information flow during cognitive processes in the brain.Keywords
This publication has 28 references indexed in Scilit:
- Transrectal Prostate Biopsy and Fiducial Marker Placement in a Standard 1.5T Magnetic Resonance Imaging ScannerJournal of Urology, 2006
- Placement of deep brain stimulator electrodes using real‐time high‐field interventional magnetic resonance imagingMagnetic Resonance in Medicine, 2005
- High‐resolution MRI reflects myeloarchitecture and cytoarchitecture of human cerebral cortexHuman Brain Mapping, 2004
- Functional Magnetic Resonance Imaging of Macaque Monkeys Performing Visually Guided Saccade TasksNeuron, 2004
- Magnetic Resonance Imaging and Deep Brain StimulationNeurosurgery, 2002
- Magnetic Resonance Imaging and Deep Brain StimulationNeurosurgery, 2002
- Ultra High-Resolution fMRI in Monkeys with Implanted RF CoilsNeuron, 2002
- Intentional Maps in Posterior Parietal CortexAnnual Review of Neuroscience, 2002
- Functional MRI of Macaque Monkeys Performing a Cognitive Set-Shifting TaskScience, 2002
- A comparison of the Two One-Sided Tests Procedure and the Power Approach for assessing the equivalence of average bioavailabilityJournal of Pharmacokinetics and Biopharmaceutics, 1987