Self–nonself discrimination by T lymphocytes
- 1 May 2004
- journal article
- Published by Cellule MathDoc/Centre Mersenne in Comptes Rendus Biologies
- Vol. 327 (5) , 399-408
- https://doi.org/10.1016/j.crvi.2004.03.003
Abstract
Tolerance of T lymphocytes to self-antigens is mainly achieved at the level of the primary lymphoid organ, the thymus, and probably to a lesser extent in the secondary lymphoid tissues. Whether self-reactive lymphocytes ignore their target autoantigen, or are tolerized by the various mechanisms discussed, depends on the circumstances.Keywords
This publication has 59 references indexed in Scilit:
- T Cell Regulation as a Side Effect of Homeostasis and CompetitionThe Journal of Experimental Medicine, 2003
- The CD8α+ Dendritic Cell Is Responsible for Inducing Peripheral Self-Tolerance to Tissue-associated AntigensThe Journal of Experimental Medicine, 2002
- Peripheral Deletion of Autoreactive CD8 T Cells by Cross Presentation of Self-Antigen Occurs by a Bcl-2–inhibitable Pathway Mediated by BimThe Journal of Experimental Medicine, 2002
- Innate Immune RecognitionAnnual Review of Immunology, 2002
- Tolerance to Islet Antigens and Prevention from Diabetes Induced by Limited Apoptosis of Pancreatic β CellsImmunity, 2002
- MATURE T LYMPHOCYTE APOPTOSIS—Immune Regulation in a Dynamic and Unpredictable Antigenic EnvironmentAnnual Review of Immunology, 1999
- Evidence for a Thymus‐Dependent Form of Tolerance that is Not Based on Elimination or Anergy of Reactive T cellsImmunological Reviews, 1996
- Self‐Ignorance in the Peripheral T‐Cell PoolImmunological Reviews, 1993
- Induction by Antigen of Intrathymic Apoptosis of CD4 + CD8 + TCR lo Thymocytes in VivoScience, 1990
- Immunobiology of Tissue Transplantation: A Return to the Passenger Leukocyte ConceptAnnual Review of Immunology, 1983