Evidence for D2 Receptor Regulation of Dopamine Release in the Goldfish Retina
- 1 December 1993
- journal article
- Published by Wiley in Journal of Neurochemistry
- Vol. 61 (6) , 2025-2033
- https://doi.org/10.1111/j.1471-4159.1993.tb07438.x
Abstract
The possible existence of a dopamine D2 receptor‐mediated regulation of dopamine release was investigated in the goldfish retina. Isolated retinas were preloaded with [3H]dopamine and superfused with D2 dopamine receptor agonists or antagonists to determine if there was an effect on [3H]dopamine release. The D2 receptor antagonist sulpiride increased both baseline [3H]‐ dopamine release and [3H]dopamine release induced by an increase in extracellular potassium concentration. The D2 receptor agonists LY‐171555 and RU‐24213 did not reduce baseline [3H]dopamine release but completely inhibited [3H]dopamine release induced by an increase in [K±]o. This action of the D2 agonists was blocked by sulpiride. These studies demonstrate the existence of D2 receptor, possibly autoreceptor, regulation of dopamine release in the teleost retina.Keywords
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