A Perspective on PEEP

Publisher Website
Google Scholar
Abstract
Controlled positive-pressure ventilation with added positive end-expiratory pressure (PEEP) is a major method of therapy for the severe hypoxemia associated with pulmonary edema, especially that associated with the persistent pulmonary edema caused by lung-capillary injury and increased capillary permeability.1 Although PEEP raises arterial oxygen tension and content in this setting, it may also lower cardiac output.2 Thus, PEEP has opposing influences on oxygen delivery to the tissues, since oxygen transport depends on the product of arterial oxygen content and cardiac output. A precise understanding of the mechanisms by which PEEP reduces cardiac output might allow more appropriate therapy. This issue . . .

This publication has 4 references indexed in Scilit: