Diagnostic Limitations of Metachromasia

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Abstract
In 1966 Danes and Bearn reported the presence of granules taking a metachromatic stain in the cytoplasm of fibroblasts cultured from the skin of patients with the genetic mucopolysaccharidoses.1 Since then similar observations in their laboratory and elsewhere have been made in over 17 diseases,2 the most common of which is cystic fibrosis. Indeed Danes and Bearn report that they are able to distinguish three varieties of cystic fibrosis that breed true to form, on the basis of the number, nature and size of the granules.3 Their contributions have stimulated many to investigate these and other diseases at the cellular . . .

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