NON-HODGKIN LYMPHOMAS - ANALYSIS OF 109 JAPANESE CASES WITH THE USE OF LSGJ CLASSIFICATION

  • 1 January 1982
    • journal article
    • research article
    • Vol. 106  (1) , 30-39
Abstract
Recently the Lymphoma Study Group of Japan (LSGJ) proposed a new classification of non-Hodgkin''s lymphomas (NHL), dividing NHL into the follicular group consisting of 3 subsets and the diffuse group, 7. Each subset of the diffuse group is further divided into B or T cell types according to immunologic markers and/or morphologic prediction. A review of 109 cases of NHL was undertaken to assess the clinicopathologic utility of this classification. Morphologic criteria, enzyme histochemistry, and immunoperoxidase technique were used to ensure the accuracy of the immunologic phenotyping. The results suggest that the LSGJ classification is easily reproducible and yields a more precise clinicopathologic correlation than traditional, morphologic classifications. Consistent with similar studies in Japan, this study demonstrated a low incidence of Hodgkin''s disease (7.6% of all lymphomas) and follicular lymphomas (8.3% of all NHL) and a high incidence of T cell lymphomas (34.9% of all NHL). The incidence (45.9%) of extranodal presentation was high. These four features seem characteristic of lymphomas in Japan.