t-Amyloxycarbonyl as a New Protecting Group in Peptide Synthesis. I. The Synthesis and Properties of N-t-Amyloxycarbonylamino Acids and Related Compounds
- 1 September 1965
- journal article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 38 (9) , 1522-1525
- https://doi.org/10.1246/bcsj.38.1522
Abstract
It has been shown that the t-amyloxycarbonyl group (AOC group) can be introduced quite readily into amino acid esters by using t-amyl chloroformate as a reagent, and that the AOC group can be cleaved as smoothly as the t-butoxycarbonyl group (BOC group) under acidic conditions. Since this reagent is much easier to prepare than any other reagents used for the introduction of the BOC group, the new procedure is considered to be of great use in the practical synthesis of complicated peptides. 3-Methyl-3-pentoxycarbonylamino acids were also prepared by following the same procedure as was used in the case of AOC-amino acids.This publication has 7 references indexed in Scilit:
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