The Anti-Rachitic Properties of Irradiated Sterols

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Abstract
Cholesterol is rendered anti-rachitic by exposure to sunlight as well as to other sources of ultra-violet light. By irradiating cholesterol in the absence of O2, the stability of the "activated" cholesterol is considerably increased. An amorphous substance which prevents rickets in rats in doses of 1/100 mgm. per day has been separated from "activated" cholesterol by precipitating the cholesterol with digitonin. Both the secondary alcohol group and the unsaturated carbon linkage of the sterol molecule must be intact for the production of anti-rachitic properties by ultra-violet light.

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