The influence of Witte's "peptone" and of digestion of blood platelets and plasma

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Abstract
Undisturbed plasma protects platelets against clumping and lysis. A concentration of Witte''s "peptone" just sufficient to inhibit the clotting of human blood augments the stabilizing influence of plasma on platelets. The anticoagulant action of "peptone" on plasma shed into paraffined vessels continues after the disintegration of platelets. The principal influence of small amounts of "peptone" on blood freshly shed into paraffined vessels is the restraint of changes in the plasma. This action, by delaying the disintegration of platelets, assists in the inhibition of clotting. Exposure of plasma to the air produces disintegration of platelets. The stability of platelets is dependent on the pressures of gases in plasma. The observations of Mills and his assistants, that platelets withdrawn from circulation during the height of digestion of a meat meal clump and disintegrate more rapidly than those obtained during either fasting or after the ingestion of a meal of rice, is confirmed.

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