FROM A study of 600 adults with migraine1 it was noted that the onset of headache frequently occurred in childhood and also that psychological factors played a prominent role in the production of the migraine attack. As a result of these observations a group of 50 children with migraine who were seen at the Headache Clinic of the Montefiore Hospital for Chronic Disease, were studied in an effort to evaluate the syndrome. A preliminary study has been published.2 By "migraine" we mean that form of recurrent headache which is characteristically unilateral, occurs in bouts usually associated with gastrointestinal and/or ocular symptoms against a background of relative well-being, and is often preceded by visual or psychological disturbances and followed by sleep. There is usually a history of similar headaches in the parents or other members of the family. The underlying causes of migraine are unknown. However, the mechanism of