Abstract
From the time oftheir discovery in the middle ofthe nineteenth century, chromosomes have held a particular fascination for cell biologists . The past 25 years-the period covered by this volume-has been no exception . During this time a host of new approaches to problems of chromosome and gene orga- nization has been introduced, beginning in the early 1950s with spectrophotometric analysis of nuclear staining and the appli- cation of autoradiography to questions of DNA and RNA

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