Phototoxic reaction to chlorpromazine as studied with the quantitative mouse tail technique
Open Access
- 1 September 1975
- journal article
- research article
- Published by Medical Journals Sweden AB in Acta Dermato-Venereologica
- Vol. 56 (5) , 373-376
- https://doi.org/10.2340/0001555556373376
Abstract
A quantitative in vivo technique for the study of the phototoxic reaction to systemic chlorpromazine has been developed, based on the increasing tissue fluid content of the albino mouse tail. A maximum increase in tissue fluid of about 25% was registered 24 hours after starting the long-wave ultraviolet light exposure. The minimum phototoxic dose of chlorpromazine was 2.5 mg/kg.This publication has 1 reference indexed in Scilit:
- The experimental production of drug phototoxicity in guinea pigs. II. Using artificial light sourcesArchives of Dermatology, 1966