Determination of loxapine in human plasma and urine and identification of three urinary metabolites
- 1 January 1979
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 9 (7) , 405-414
- https://doi.org/10.3109/00498257909038745
Abstract
1. A g.l.c. method for quantitative determination of loxapine (2-chloro-11 -(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)oxazepine), in human plasma and urine is described. 2. Preliminary pharmacokinetic data on plasma concn of loxapine over 12 h from five psychiatric patients who received a total average dose of 80 mg of loxapine succinate per day orally for twelve weeks are presented. 3. In addition to unchanged loxapine, three urinary metabolic products, namely aromatic ring-hydroxy loxapine, desmethyl loxapine and loxapine-N-oxide, were identified using g.l.c—mass spectrometry.This publication has 3 references indexed in Scilit:
- Clinical and plasma level characteristics of intramuscular and oral loxapinePsychopharmacology, 1978
- The Identification of Four Metabolic Products after Incubation of p -Methoxyamphetamine with Liver Preparations of Various SpeciesXenobiotica, 1974
- Distribution and metabolism of doxepinBiochemical Pharmacology, 1969