Tumour‐associated antigen CA 125 in patients with ovarian cancer

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Abstract
The serum levels of antigen CA 125 expressed by epithelial ovarian carcinoma were measured in 27 postmenopausal women with ovarian tumors and in 16 controls. Increased serum levels of CA 125 were found in 9 (75%) out of 12 patients with ovarian cancer; in 3 with stage I disease levels were not elevated. No significant difference was found in the concentration of CA 125 detected in peripheral or ovarian venous blood. Decreased antigen levels were found 6-30 wk after radical operation and cytostatic chemotherapy in the ovarian cancer group. The results indicate the value of measuring CA 125 as a tumor marker in the follow-up of ovarian cancer.