Poor Agreement among Prothrombin Time International Normalized Ratio Methods: Comparison of Seven Commercial Reagents
Open Access
- 1 March 2005
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 51 (3) , 553-560
- https://doi.org/10.1373/clinchem.2004.043836
Abstract
Background: Prothrombin time (PT) has long been the most popular test for monitoring oral anticoagulation therapy. The International Normalized Ratio (INR) was introduced to overcome the problem of marked variation in PT results among laboratories and the various recommendations for patient care. According to this principle, all reagents should be calibrated to give identical results and the same patient care globally. This is necessary for monitoring of single patients and for application of the results of anticoagulation trials and guidelines to clinical practice.Keywords
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