HEMODIALYSIS, PERITONEAL-DIALYSIS, PLASMAPHERESIS AND FORCED DIURESIS FOR THE TREATMENT OF QUININE OVERDOSE

  • 1 January 1981
    • journal article
    • research article
    • Vol. 16  (5) , 264-268
Abstract
Peritoneal dialysis, hemodialysis, plasma exchange and forced diuresis accelerated removal of quinine following quinine poisoning. All these modalities were used simultaneously to treat a 19 yr old youth who had become blind as a result of an overdose of quinine tablets. The serum qunine level was measured at 10.5 .mu.g/ml 13 h after quinine ingestion. Forced diuresis accounted for the removal of 557 mg of quinine in the first 5 h and a total of 1625 mg over 75 h A 6 h hemodialysis recovered 30 mg of quinine while peritoneal dialysis removed an average of 1.6 mg/h over the first 48 h. Plasmapheresis over 3 h exchanged 2 l of plasma containing a total of 8.5 mg of quinine. Some vision returned 19 h after quinine ingestion but did not become normal until 51/2 mo. later. Apparently hemodialysis, peritoneal dialysis and plasma exchange made only a minor contribution to quinine elimination by comparision with renal excretion of quinine.

This publication has 0 references indexed in Scilit: