Lack of Synergistic Relationship Between Thyroid and Salivary Gland Function

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Abstract
Salivary glands are thought to play no active role in metabolism of such thyroid analogues as Diiodotyrosine (DIT) in the dog. The amount of I cleared into the saliva appears to be strictly a function of the circulating plasma level of iodide ion and is not influenced by exogenous thyroid hormone. This clearance will depend upon the rates with with which exogenous diiodotyrosine, thyroxine and triiodo-thyronine become deiodinated. Since neither dog nor rat salivary glands appear to contain a DIT deiodinase system such as found in liver and kidney tissue, it is concluded that these glands are not involved in the metabolism of DIT nor in the control of the circulating blood level of this analogue.

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