Effect of Dietary Lipid upon Some Enzymes of Significance in Biogenic Amine Metabolism in the Rat

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Abstract
Activities of certain enzymes concerned with biogenic amine metabolism were influenced significantly by the dietary lipid. Monoamine oxidase, 5-hydroxytryptophan decarboxylation, and in vitro metabolism of 5-hydroxytryptophan to end products were highest in livers from rats fed 7% levels of cod liver oil, linseed oil, corn oil or a combination of linseed and cod liver oils, in comparison with similar data from animals fed beef fat or low levels of corn oil. No differences were found in brain enzyme activity among the experimental groups. Fatty acids from liver phospholipids reflected the differences due to the dietary lipid, but no significant differences were found in liver lipid content, or in liver and brain nitrogen, RNA, and DNA levels.