Effects of Vitamin C Loading on Serum Constituents in Man

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Abstract
Loading doses of vitamin C in volunteer subjects produce a variety of changes in serum components. When the grouped means of baseline studies are compared with the results of 12 wk of vitamin C loading (3.0 g/day), there are significant differences. Serum ascorbic acid, lactate dehydrogenase and albumin all show increases; Na, uric acid, alanine aminotransferase and globulins are significantly decreased when evaluated by Student''s t test. Although biweekly variations in the lipid parameters of serum cholesterol, HDL [high density lipoprotein] cholesterol, triglyceride, lecithin:cholesterol acyltransferase activity, and bile acids were found, there were no significant differences in the grouped means for baseline and experimental periods. There was a significant increase in leukocyte ascorbic acid, but no other change in cell distribution or number.