CANCEROSTATICA .2. SYNTHESIS AND PRELIMINARY CYTOSTATIC SCREENING OF SOME ALPHA-CARBOLINE DERIVATIVES

  • 1 January 1978
    • journal article
    • research article
    • Vol. 30  (4) , 569-572
Abstract
6-Phenyl- and (6-pyridyl-3'')-2-chloro-3-aminopyridines were transformed by treatment with HNO3 into the corresponding pyrido[4,5-b]triazoles[7,8]. In PPA [polyphosphoric acid] medium at 180.degree. C, triazoles 7 and 8 decompose to 2-substituted .alpha.-carbolines 9, 10 and anilino-3-hydroxypyridines 11, 12. Some of these compounds showed significant cytostatic activity against Ehrlich ascites carcinoma and Nemeth-Kellner lymphoma [mouse tumors].

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