Amino Acids and Peptides; 60.1Synthesis of Biologically Active Cyclopeptides; 10. Synthesis of 16 Structural Isomers of Dolastatin 3; II:2Synthesis of the Linear Educts and the Cyclopeptides

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Abstract
Sixteen isomers of the cancerostatic cyclopeptide Dolastatin 3 of marine origin are synthesized. The proposed structure of Dolastatin 3 is proved to be not correct.