Variability within α- and β-adrenoreceptor genes as a predictor of cardiovascular function at rest and in response to mental challenge

Publisher Website
Google Scholar
Abstract
To investigate the association between polymorphic variation in α- and β-adrenoreceptor genes and cardiovascular activity at rest and in response to psychological challenge in a sample in which the heritability of these cardiovascular phenotypes may be established. Several common polymorphisms were characterized within ADRA1B (α1B), ADRA2A (α2A), ADRB1 (β1) and ADRB2 (β2) and examined in relation to heart rate (HR) and systolic (SBP) and diastolic (DBP) blood pressure, both at rest and in response to stress. Participants were 309 European-American, young adult men and women (including 101 monozygotic and 44 dizygotic twin pairs). In the full sample, participants carrying any G allele at base pair (bp) 1165 in ADRB1 exhibited elevated resting SBP and DBP and a larger DBP response to mental challenge compared to homozygotes for the C allele (PConclusions These results indicate that some polymorphic variation within adrenoreceptor genes contributes to interindividual variability in resting SBP and DBP and in DBP response to mental challenge.