LACK OF EFFECT OF TREATMENT WITH OESTROGEN IN ADVANCING PUBERTY IN THE GUINEA-PIG

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Abstract
Guinea-pigs were injected with 500 ng oestradiol benzoate or 0·1 ml arachis oil at 0, 5, 10, 20 or 25 days of age, or 2 μg oestradiol benzoate/100 g body wt at 25 days, in order to determine whether puberty would be advanced, as in the rat. It was not. Repeated injections of 100 ng oestradiol benzoate or 0·1 ml arachis oil for 5 days beginning at 0, 10, 20 or 25 days of age, or 2 μg oestradiol benzoate/100 g body wt beginning at 25 days, were similarly ineffective.