Cortisol Metabolism and Visceral Obesity: Role of 11β‐Hydroxysteroid Dehydrogenase Type I Enzyme and Reduced Co‐factor NADPH
- 1 January 2003
- journal article
- Published by Taylor & Francis in Endocrine Research
- Vol. 29 (4) , 411-418
- https://doi.org/10.1081/erc-120026947
Abstract
Several factors including genetic and environmental play a role in the development of obesity and the metabolic syndrome. The transgenic mouse overexpressing 11β‐hydroxysteroid dehydrogenase (11β‐HSD) develops visceral obesity. However, it remains unclear how a ubiquitously expressed 11β‐HSD1 enzyme affects adipose tissue so much that it would lead to obesity. In this commentary we explore the possibility that increased intracellular availability of reduced co‐factor, NADPH, could exacerbate the enzymatic activity.Keywords
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