Multiple relationships between rate of oxidative phosphorylation and Δµ̃H in rat liver mitochondria
- 2 December 1985
- journal article
- Published by Wiley in FEBS Letters
- Vol. 193 (2) , 276-282
- https://doi.org/10.1016/0014-5793(85)80168-x
Abstract
The relationship between rate of ATP synthesis and transmembrane electrochemical proton gradient has been determined in rat liver mitochondria oxidizing succinate, using the respiratory inhibitor malonate or the uncoupler FCCP to decrease Δµ̃H progressively. As previously reported [(1982) Eur. J. Biochem. 126, 443‐451] two different relationships are obtained depending on the method used. Evidence is presented that this result is not due to underestimation of the Δµ̃H maintained by fast‐respiring mitochondria, as recently suggested [(1985) FEBS Lett. 181, 323‐327].Keywords
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