Pteridine and Riboflavin in Tumor Tissue and the Effect of Chloramphenicol and Isoxanthopterin

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Abstract
Human squamous cell carcinoma has elevated levels of tetrahydrobiopterin. As the level of riboflavin is low, the ratio tetrahydrobiopterin/riboflavin shows values of 5 - 8.3. In contrast, in differentiated tissues with high metabolic activity but low mitotic rate, like submaxillary glands, elevated levels of tetrahydrobiopterin are accompanied by high content of riboflavin. Thus the ratio tetrahydrobiopterin/riboflavin in kept as low as about 0.5. Chloramphenicol and, in particular, isoxanthopterin reduce tumor growth in rats and prevent tetrahydrobiopterin accumulation as well.

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