PAF antagonistic activity of some thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepines.
- 1 January 1987
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 35 (5) , 2119-2121
- https://doi.org/10.1248/cpb.35.2119
Abstract
Some thieno [3,2-f] [1,2,4] triazolo[4,3-a] [1,4] diazepines were antagonistic to PAF-induced platelet aggregation in rabbit PRP and bronchoconstriction in guinea pigs. A study of structure-activity relationships demonstrates that the fused triazolo ring with a lower alkyl group is crucial for the activity. Among these compounds, etizolam was the most potent and specific antagonist of PAF.This publication has 12 references indexed in Scilit:
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