Transplantation of Bursal Stem Cells into Cyclophosphamide-Treated Chicks.

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Abstract
After transplantation of bursal stem cells into cyclophosphamide-treated newly hatched chicks, the 1st lymphoid cells in the spleen of the recipients were observed on the 1st day after the cell transfer, and the first plasma cells on day 3. The repopulation of the Schweigger-Seidel sheaths started from their periphery on day 6. The first germinal centers were detected 20 days after the cell transfer. In cyclophosphamide-treated birds without cell transplantation, only the periphery of the Schweigger-Seidel sheaths became repopulated, and no plasma cells or germinal centers were observed. By the age of 3 days, the bursa probably contains some cells of postbursal maturity able to home to the spleen.