Pulmonary vasoconstriction during histotoxic hypoxia
- 1 May 1965
- journal article
- research article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 20 (3) , 488-490
- https://doi.org/10.1152/jappl.1965.20.3.488
Abstract
Increases in pulmonary vascular resistance could be produced in excised perfused ventilated dog lung lobes by lowering the alveolar Po2. When dinitrophenol was added to the perfusate a similar change in the vascular bed occurred that could be reversed by ventilating with supernormal oxygen concentrations. The similarity of the responses to dinitrophenol and lowered alveolar Po2 was demonstrated using normally and retrogradely perfused lobes. The hypoxic pressor response was shown to be independent of the Po2 of blood contained in the arteries and veins. Note: (With the Technical Assistance of Emily McCartney) dinitrophenol; cyanide; vascular effect of intravascular oxygen concentration Submitted on August 13, 1964This publication has 3 references indexed in Scilit:
- Effect of alveolar hypoxia on pulmonary vascular resistanceJournal of Applied Physiology, 1964
- PULMONARY VASOCONSTRICTION IN RESPONSE TO PRECAPILLARY HYPOXEMIA*Journal of Clinical Investigation, 1963
- The site of action of anoxia on the pulmonary blood vessels of the catThe Journal of Physiology, 1954