Four methodologies based on the aza-Wittig reaction have been used for the preparation of the wide variety of nitrogen-containing natural products. The synthesis of quinoline, β-carboline, pyrimidine, oxazole and imidazole alkaloids, by using these methodologies are presented. 1 Introduction 2 Intramolecular aza-Wittig Reaction 3 Tandem aza-Wittig/Electrocyclic Ring-Closure 4 Tandem aza-Wittig/Heterocumulene-Mediated Annelation 5 Tandem aza-Wittig/Intramolecular Halide Displacement