Comparative Study of the Effect of CV-6209, a Specific PAF-Antagonist, on Rat Paw Edema Caused by Different Phlogogen Agents
- 1 January 1990
- journal article
- research article
- Published by S. Karger AG in Pharmacology
- Vol. 40 (4) , 211-217
- https://doi.org/10.1159/000138661
Abstract
Comparative effects of CV-6209, a potent and specific platelet activating factor (PAF) antagonist, on PAF-acether-, carrageenin-, histamine-, serotonin-, compound 48/80-, dextran-, zymosan A- and arachidonic acid-induced rat paw edema were investigated. CV-6209 has proven to be effective in PAF-induced edema, but it also showed a significant activity in other models of paw edema, except those induced by zymosan A and arachidonic acid. Other drugs tested, namely indometacin, mepyramine, methysergide and nordihydroguaiaretic acid showed a more selective inhibitory profile. These results suggest an important role of PAF in the inflammatory process caused by intraplantar injection of different phlogogens in the rat paw.This publication has 2 references indexed in Scilit:
- Salicylates inhibit paf-acether-induced rat paw oedema when cyclooxygenase inhibitors are ineffectiveProstaglandins, 1986
- Effects of inhibitors of some mediators on the paw-edema induced by acetyl glyceryl ether phosphorylcholine in rats.Folia Pharmacologica Japonica, 1986