Nonopsonic Phagocytosis of Erythrocytes Infected with Ring-StagePlasmodium falciparum
- 1 April 2005
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 73 (4) , 2559-2563
- https://doi.org/10.1128/iai.73.4.2559-2563.2005
Abstract
Ring-stage parasitized erythrocytes (RPEs) were demonstrated to interact with effector cells of the innate immune system. With receptor blockade studies and CD36-null macrophages, human and murine macrophages were shown to phagocytose RPEs through the pattern recognition receptor CD36. These in vitro data implicate scavenger receptors in the clearance of RPEs.Keywords
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