Abstract
A review of the mechanisms through which gene differences may produce behavior differences. Gene action may occur at the level of gross organ structure, cell arrangement, or molecular arrangement. Organ defects of genetic origin are known to influence behavior. Variability in neuron arrangement in the normal nervous system is known, but not its significance for behavior and genetic background. The sensitivity of different genetic strains to hormones varies, and this factor influences behavior. Sound-induced convulsions in strains of inbred mice are excellent material for investigating the physiol.genetics of behavior. Differences in time constants of the nervous system have been demonstrated between susceptible and non-susceptible strains, and the hypothesis that these differences are the result of variation in enzyme systems has been advanced. A coordinated attack on the problem by workers in many fields is needed.