RENOTROPIC EFFECTS OF SOME ANDROGENS UPON EXPERIMENTAL HYDRONEPHROSIS AND UPON THE CLITORIS IN THE MOUSE1

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Abstract
Bioassay technics were developed in mature female mice for the study of the androgenic and renotropic effects of steroid hormones. One ureter was ligated and 0.1-2.5 mg. of the steroids were given in oil every other day for 30 days. In control animals complete fibrosis of renal parenchyma followed ureteral ligation. Testosterone propionate and methylandro-stenediol afforded limited protection to tubular cells, whereas cis-testosterone, vinyl testosterone, methylandrostanediol, free testosterone, testosterone-beta-diethylaminoethyl carbonate and testosterone tocaptate were ineffective in preserving renal parenchyma. Some of these substances nevertheless caused varying degrees of hypertrophy of the contralateral kidney. A good correlation between dosage of testosterone propionate, hypertrophy of the healthy kidney and increase of the clitoris was found. These 2 characteristics may express the androgenicity of steroids, whereas the degree of histological protection in the hydronephrotic kidney may reflect other properties of substances tested.